Immune Inflammatory Response

Immune Inflammatory Response

To the tune of “Drivers License” by Olivia Rodrigo

[Verse 1]
Macrophages produce cytokines
Which act on various effectors
Such as the hypothalamus
Increasing body temperature
This increases the efficiency of macrophage phagocytosis

[Verse 2]
Cytokines act on blood vessels
Causing vasodilation
They allow for adhesion
Of cells to the endothelium
Through the increased expression of receptors on the endothelium

[Chorus]
An effective immune response requires cells to migrate
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation

[Verse 3]
Once cells leave the blood vessels
They travel to the infection
Using chemokine receptors
To move down chemotactic gradients
Cytokines travel through the body and interact with tissues and organs

[Chorus]
An effective immune response requires cells to migrate
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation

[Bridge]
Selectins, integrins, allow for leukocytes
To adhere, right near the infection site
Immunoglobulins are ligands for the integrin family
(Ooh, ooh, ooh, ooh)
Integrins and ICAM, bind tightly sending
A signal to the endothelial coating
So that the leukocytes can exit the blood vessels
(Ooh, ooh, ooh, ooh)

[Chorus]
An effective immune response requires cells to migrate
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation