Antigen Presentation

Antigen Presentation

To the tune of “Potential Breakup Song” by Aly & AJ 

[Verse 1]
Endogenous, endogenous, endogenous cellular pathway
It interacts with the CD8
The CD8 plus killer T-cells, the killer T-cells
Recognizes, recognizes, recognizes peptides produced
Within the cell through the use
Of the MHC class I protein, the class I protein

 [Pre-Chorus]
MHC I is comprised of only one peptide
The binding cleft
Binds peptides eight to ten residues in length
It is limited

[Chorus] 
Antigen presentation requires MHC
To facilitate tight binding between
The T-cell and fragmented protein
Antigen presentation requires MHC

 [Post-Chorus]
Each T-cell
It has a receptor
Known as a TCR
These are highly unique

[Verse 2]
Exogenous, exogenous, exogenous pathway uses
The protein MHC class II
Interacts with CD4 T-cells, the helper T-cells

[Pre-Chorus] 
The protein is formed by two unique polypeptides
MHC class II
The interactions between β and α1
Form the peptide groove

 [Chorus] x2
Antigen presentation requires MHC
To facilitate tight binding between
The T-cell and fragmented protein
Antigen presentation requires MHC

[Post-Chorus]
 Each T-cell
It has a receptor
Known as a TCR
These are highly unique 
Each T-cell
It has a receptor
They are highly diverse
And recognize antigens and MHC