The Crossbridge Cycle

The Crossbridge Cycle

To the tune of “Crazy Classic Life” by Janelle Monae

[Verse 1]
The binding of ATP
To myosin (Oh-oh, oh-oh, oh-oh, oh-oh)
Reduces affinity
For actin (Oh-oh, oh-oh, oh-oh, oh-oh)
Myosin will detach
ATP is hydrolyzed (Oh-oh, oh-oh, oh-oh, oh-oh)
Energy that is released
Makes myosin energized (Oh-oh, oh-oh, oh-oh, oh-oh) 

[Pre-Chorus]
Myosin remains bound
To Pi and ADP (Oh-oh, oh-oh, oh-oh, oh-oh)
Energized myosin
Has a high affinity (Oh-oh, oh-oh, oh-oh, oh-oh)
For actin filaments

[Chorus]
This is the crossbridge cycle
This is the crossbridge cycle
Causes contraction of muscle
Through the crossbridge cycle 

[Verse 2]
The binding of myosin
To actin filaments (Oh-oh, oh-oh, oh-oh, oh-oh)
Triggers release of Pi
And myosin to pivot (Oh-oh, oh-oh, oh-oh, oh-oh)
This is the power stroke
Causes conformational change (Oh-oh, oh-oh, oh-oh, oh-oh)
Shifting myosin
Into its low energy state (Oh-oh, oh-oh, oh-oh, oh-oh)

[Pre-Chorus]
ADP is then released
Actin and myosin (Oh-oh, oh-oh, oh-oh, oh-oh)
Remain tightly bound
Till the cycle rebegins (Oh-oh, oh-oh, oh-oh, oh-oh)
With ATP binding

[Chorus]
This is the crossbridge cycle
This is the crossbridge cycle
Causes contraction of muscle
Through the crossbridge cycle
This is the crossbridge cycle
This is the crossbridge cycle
Causes contraction of muscle
Through the crossbridge cycle
The crossbridge cycle