T Cell Immunity Regulation

T Cell Immunity Regulation

To the tune of “I Will Survive” by Gloria Gaynor

[Verse 1]
If there are too few peptide-MHC complexes 
The naive T cells, they will not be activated
The activation threshold has too high a requirement
And so these cells, they remain ignorant
Negative selection
Removes auto-reactive T cells through clonal deletion
And those that do escape, deleted they will be
By induction of apoptosis in the periphery

[Pre-Chorus]
Just signal one all alone
Can lead to apoptotic pathway activation
No co-stimulation by CD28
Means that anti-apoptotic genes are not upregulated

[Chorus]
These responses regulate
Effector T cells so they don’t cause damage through inflammation
T cell regulation has mechanisms
That help induce a healthy immune response

[Verse 2]
Lack of co-stimulation can cause anergy
Anergic cells can function regulatorily
Like if  IL-2  is consumed by anergic cells
This can prevent T cell proliferation as well
Signal one upregulates
GRAIL and Cbl-b which are ubiquitin ligases
Parts of the TCR are ubiquitinated
Thus it becomes a target for protein degradation

[Pre-Chorus]
The T cells that regulate
Kill effector T cells with methods like CD8s
Such as the release of granzyme and perforin
Or chronic stimulation leading to exhaustion

[Chorus]
These responses regulate
Effector T cells so they don’t cause damage through inflammation
T cell regulation has mechanisms
That help induce a healthy immune response