Antibody Effector Function

Antibody Effector Function

To the tune of “We Are the Champions” by Queen 

[Verse 1]
Neutralization
Of pathogen
Involves binding of antibodies
To antigens
 This is mainly
Carried out by
The IgA and IgG isotypes
Which require isotype switching

[Chorus]
 Isotypes of antibodies
IgA, D, G, M, and E
Their effector function includes neutralization
Complement activation and degranulation
Of mast cells

[Verse 2] 
Classical pathway
Of complement
Is activated primarily
By IgM
This leads to release
Of mediators
Of inflammation and opsonization of pathogens
And formation of the membrane attack complex

 [Chorus] x2
Isotypes of antibodies
IgA, D, G, M, and E
Their effector function includes neutralization
Complement activation and degranulation
Of mast cells