Nucleoprotein Switch

Nucleoprotein Switch

To the tune of “I Am Not a Robot” by MARINA

[Verse 1]
RdRP attaches to
The 3’ end and starts to produce
mRNA
From the negative template
After synthesis of one mRNA
There is pausing of the polymerase
Then it reinitiates
Along the template

[Pre-Chorus]
This start and stop
This start and stop
Is controlled by
The levels of
The levels of
Nucleoprotein

[Chorus]
Nucleoprotein
Is an anti-terminator
Anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator

[Verse 2]
When infection is only beginning
Low levels of nucleoprotein
Will favour
Synthesis of proteins
As levels of NP start to escalate
NP binds the negative RNA template
Preventing starting and stopping
Of the polymerase

[Pre-Chorus]
This will promote
This will promote
Synthesis of genome
Which is the full
Which is the full
Length RNA

[Chorus]
Nucleoprotein
Is an anti-terminator
Anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator

[Bridge]
Amount of NP will act as
A switch to determine
What is preferred

[Chorus]
NP
Is an anti-terminator
NP
Is an anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator
Nucleoprotein
Is an anti-terminator
Anti-terminator