Brown Adipose Tissue

Brown Adipose Tissue

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To the tune of “Love is a Wild Thing” by Kacey Musgraves

[Verse 1]
Norepinephrine released by sympathetic nerves
Will bind with beta-3 adrenergic receptors

 [Pre-Chorus]
This activates G proteins to stimulate
Breakdown of triglycerides by a lipase

 [Chorus]
The main thermogenic effector organ
Is brown adipose tissue
It has an extensive blood supply
To provide with it O2
It transports warmed blood via Sultzer’s vein
In order to maintain
Temperature

[Verse 2] 
Free fatty acids directly activate
UCP-1 and provide ETC substrate

 [Pre-Chorus]
The proton motive force will be generated
Through UCP-1 protons leak back into the matrix

 [Chorus]
The main thermogenic effector organ
Is brown adipose tissue
It has an extensive blood supply
To provide with it O2
It transports warmed blood via Sultzer’s vein
In order to maintain
Temperature

 [Bridge]
Proton leak collapses membrane potential
So metabolism must accelerate

  [Chorus]
The main thermogenic effector organ
Is brown adipose tissue
It has an extensive blood supply
To provide with it O2
It transports warmed blood via Sultzer’s vein
In order to maintain
In order to maintain
In order to maintain
Temperature