Antibiotics

Antibiotics

To the tune of “Baby” by MARINA

[Verse 1]
The main use for microbes in the pharmaceutical industry
Is producing metabolites with therapeutic properties
Such as β lactams
Including penicillins
These are products of microbial biotechnology

[Pre-Chorus]
Antibiotics inhibit
Many bacterial processes
But they do not affect eukaryotes

[Chorus]
Like the synthesis
Of folic acid
Or peptidoglycan
These mechanisms
They specifically target 
Bacterial cells
Bacteria
Bacterial cells
They specifically target

[Verse 2]
Secondary metabolites are not growth associated
They are often produced during the stationary phase
Use of bioreactors
To control temperature
And other factors including aeration and the pH

[Pre-Chorus]
Antibiotics inhibit
Many bacterial processes
But they do not affect eukaryotes 

[Chorus]
Many inhibit
Protein synthesis
Macrolides bind the 50 subunit
Block transfer of the peptide
Preventing elongation
Aminoglycosides
Interfere with the ability to bind
Of the tRNA
With the mRNA codon
They specifically target 
Bacterial cells
Bacteria
Bacterial cells
They specifically target 

[Bridge]
The drug chloramphenicol
Obstructs the formation of peptide bonds
Binds 23s rRNA
It specifically targets

[Chorus]
Bacterial cells
Bacteria
Bacterial cells
They specifically target