Pathogenesis

Pathogenesis

To the tune of “Here Comes A Thought” from Steven Universe

[Intro]
A disease caused by a microbe
Transmitted from host to host
A disease caused by a microbe
Transmitted from host to host 

[Verse 1]
Pathogenesis of various microbes
Causes disease in different types of hosts
Production of virulence factors
Including toxins and proteins for attachment

[Pre-Chorus]
Oh, microbes attach, using fimbriae
That can be modified to help evade
The immune system
Limits resistance 

[Chorus]
E. coli has a system
Using Tir and Intimin
Through type III secretion
Adds Tir into the membrane
Where it binds, where it binds, where it binds, where binds
To the bacterial protein known as Intimin
And it forms, and it forms, and it forms a pedestal structure
For nutrient capture

[Verse 2]
Pathogenesis of various microbes
Causes disease in different types of hosts
Production of virulence factors
Including toxins and proteins for attachment 

[Pre-Chorus]
Oh, bacteria produce toxins
That promote disease by causing
Large immune response
Leads to septic shock

[Chorus]
Endo- and exotoxins
Produce inflammation
Such as the A-B toxins
Common in many pathogens
The A portion has toxic enzymatic activity
The B portion is what binds to host cell receptors
Diphtheria toxin enters the cytoplasm
Abolishing translation 

[Bridge]
Exotoxins include diphtheria, pertussis, and cholera
Work by ADP-ribosylation of molecules
Cytolysins act upon the membrane of the cell
Encourage lysis as well

[Outro]
A disease caused by a microbe
Transmitted from host to host
A disease caused by a microbe
Transmitted from host to host