Oncolytic Viruses

Oncolytic Viruses

To the tune of “You Make It Feel Like Christmas” by Blake Shelton and Gwen Stefani

[Verse 1]
Impaired interferon signaling
In human cancer cells is a common thing
This will permit viruses
To replicate in these cells

[Verse 2]
A good viral vector has properties
Like a large packaging capacity
Along with a very low
Seroprevalence in humans

[Chorus]
Must also be non-pathogenic
Have stable transgene expression
And grow to high titer
For production logistics
Tropism can be amended
To change which cells are infected
Adenoviruses are used most commonly

[Verse 3]
The target virus can be altered
To bind receptors of cells with cancer
Through the changing of
Specific amino acids

[Chorus] 
Or domains can be inserted
Into virus fibers
So that they can recognize
Tumor antigens
Viral vector efficacy
Can be increased easily
Through the adding of immunostimulatory factors

 [Verse 4]
There can be changes in fusion proteins
To increase fusogenic properties
To increase the formation
Of syncytia

  [Outro]
These modifications can increase vector efficacy
These modifications can increase vector efficacy