Biological Clocks

Biological Clocks

To the tune of “Someone Like You” by Adele

[Verse 1]
PER was the first gene
Identified to control rhythmicity
The second gene that was discovered
Was called timeless or TIM for short
PER and TIM levels of RNA
Are low in the morning and increase through the day

[Pre-Chorus] 
PER is phosphorylated
By double time preventing degradation
In this state it can bind with TIM
And move to the nucleus

[Chorus]
Biological clocks are genetically controlled
They are also adjustable
They can be reset
By environmental effects
Such as light and noise known as zeitgebers
Such as light and noise known as zeitgebers

[Verse 2]
Transcription of PER and TIM
And other clock controlled genes is activated by
The CYC/DCLK heterodimer
Which is inhibited by TIM and PER

[Pre-Chorus]
PER and TIM are broken down by
Cryptochromes activated by morning light
This removes inhibition on the CYC/DCLK complex
Letting the cycle repeat

[Chorus]
Biological clocks are genetically controlled
They are also adjustable
They can be reset
By environmental effects
Such as light and noise known as zeitgebers
Such as light and noise known as zeitgebers

[Bridge]
Temperature does not affect these clocks
When it changes they will remain
Accurate regardless of any fluctuations

[Chorus] x2
Biological clocks are genetically controlled
They are also adjustable
They can be reset
By environmental effects
Such as light and noise known as zeitgebers
Such as light and noise known as zeitgebers